[对于无形性贫血的当前治疗策略]
1Department of Hematology, Institute of Medicine, University of Tsukuba.
像免疫抑制疗法和干细胞移植这样的无形成性贫血治疗方法正在改善生存率. 未来的挑战包括管理复发,克隆进化和这种骨髓衰竭综合征患者的长期并发症.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 无形性贫血是一种骨髓衰竭综合征,伴有低成形和全细胞减小.
- 通常是由T细胞介导的自身免疫驱动的,它需要进行血液形成恢复的干预.
研究的目的:
- 审查目前和不断发展的无形性贫血治疗策略.
- 突出血造干细胞移植和长期患者管理方面的进展.
主要方法:
- 关于无塑性贫血治疗方式的当前文献的综述.
- 分析与免疫抑制疗法,TPO-RAs和各种allo-SCT方法相关的结果.
主要成果:
- 与TPO-RAs和免疫抑制剂的联合治疗是标准的选择.
- 用带血和平分异性 allo-SCT 改善的结果扩大了治疗的可能性.
结论:
- 增强的治疗选择改善了无塑性贫血的结果和预期寿命.
- 管理复发,克隆进化和移植后晚期并发症是未来的关键挑战.
更多相关视频
11:55Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
Published on: March 14, 2011
09:29Clinical Application of Sleeping Beauty and Artificial Antigen Presenting Cells to Genetically Modify T Cells from Peripheral and Umbilical Cord Blood
Published on: February 1, 2013
相关概念视频
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
Stem Cell Therapy for Tissue Regeneration
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Targeted Cancer Therapies
There are several types of targeted therapies against...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Regulation of Hematopoietic Stem Cells
Peripheral Artery Disease III: Interprofessional Care
