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Updated: Jan 14, 2026

Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation
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Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation

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在VPS18的突变导致中性粒细胞成熟缺陷与干扰的囊泡平衡相关联

Jincheng Gao1, Almke Bader1, Monika I Linder2

  • 1Institute of Cardiovascular Physiology and Pathophysiology, Biomedical Center, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.

Cell death & disease
|January 12, 2026
PubMed
概括

通过确保适当的囊泡贩运,VPS18对中性粒细胞发育至关重要. 它的缺乏会损害中性粒细胞的成熟,导致细胞数量减少和感染增加,突出其在先天性中性粒细胞衰竭中的作用.

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An Optical Assay for Synaptic Vesicle Recycling in Cultured Neurons Overexpressing Presynaptic Proteins

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