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Updated: Jan 14, 2026

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
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通过向CD11b+ Bregs,抑制RAS/MEK/PI3K通路增加了对CD40激动反应的响应,从而克服了黑色素瘤PD1耐药性

Chi Yan1,2,3,4, Weifeng Luo5,6, Jinming Yang5,6

  • 1Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA. chi.yan@umanitoba.ca.

Nature communications
|January 12, 2026
PubMed
概括

针对BRAF野生型黑色素瘤耐免疫检查点阻塞的新组合疗法显示出有前途. 将RAS/PI3K/AKT和MEK抑制剂与CD40和抗PD1激素结合起来,通过抑制抑制性B调节细胞来克服耐药性.

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