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Updated: Jan 14, 2026

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小分子拼接调节器破坏了O-GlcNAc的平衡

Steven S Cheng1, Alison C Mody1, Amedeo Vetere2

  • 1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.

Nature communications
|January 12, 2026
PubMed
概括

药物重新定位屏幕识别了酶抑制剂,通过调节拼接来破坏O-GlcNAc的平衡. 这些化合物降低了O-GlcNAc转移酶 (OGT) 和O-GlcNAcase (OGA) 的下调,独立于它们已知的标.

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