相关实验视频

Updated: Jan 14, 2026

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts

Published on: April 29, 2014

跨队列的抵抗体和病毒体梯度构建了结直肠癌微生物群

AbdulAziz Ascandari¹, Suleiman Aminu^2,3, Rachid Benhida^2,4

¹College of Chemical Sciences and Engineering (CCSE), Chemical and Biochemical Sciences (CBS), Mohammed VI Polytechnic University (UM6P), Benguerir, 43150, Morocco. abdulaziz.ascandari@um6p.ma.

NPJ biofilms and microbiomes

|January 12, 2026

概括

肠道的微生物群.

科学领域:

微生物组研究的研究.
结肠直肠癌 (CRC) 研究研究
转基因组学是指转基因组学.

背景情况:

肠道微生物组在结直肠癌 (CRC) 中的作用很重要,但不同人群的功能模式尚不清楚.
了解这些功能特征对于开发CRC有效的诊断和治疗策略至关重要.

研究的目的:

在结直肠癌患者的肠道微生物群中表征抗菌素耐药性 (抵抗性) 和毒性因子 (病毒组) 模式.
为了确定与不同地理群体的CRC进展相关的肠道微生物组内可复制的功能梯度.

主要方法:

来自三个不同的地理群体的500多个样本的基于装配的元基因组学分析.
应用交叉验证的部分最小方程 (PLS) 回归框架来分析抗体和病毒体数据.
开发一个双轴指数 (DAI) 来表示健康,腺瘤和癌症状态的功能变化.

主要成果:

确定了两个可复制的潜伏功能梯度,结构化了抗微生物耐药性和毒性因子概况.
一个梯度突出了粘附,排泄和生物膜功能;第二个侧重于免疫调节和屏障通路.
双轴指数 (DAI) 提供了可解释的,低维的CRC阶段的功能差异表示.

结论:

在CRC中肠道微生物组的功能基因配置文件沿可复制的统计轴组织起来.
粘附,铁相关和免疫相互作用通路是CRC相关微生物组中的关键功能模块.
这项研究为研究CRC微生物组在不同种群中的功能组织提供了一个强大的框架.

更多相关视频

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

Published on: February 28, 2018

Compost Microcosms as Microbially Diverse, Natural-like Environments for Microbiome Research in Caenorhabditis elegans

Compost Microcosms as Microbially Diverse, Natural-like Environments for Microbiome Research in Caenorhabditis elegans

Published on: September 13, 2022

相关概念视频

Bacterial Flora of the Large Intestine

Bacterial Flora of the Large Intestine

The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.

Bacterial Phylum Verrucomicrobiota

Bacterial Phylum Verrucomicrobiota

The phylum Verrucomicrobiota comprises at least four characterized orders, with most species classified within the order Verrucomicrobiotales. Members of this phylum are either aerobic or facultatively aerobic, with the ability to ferment sugars. A notable exception is the genus Methylacidiphilum, which consists of aerobic methanotrophs. Additionally, some Verrucomicrobiota establish symbiotic relationships with protists. These bacteria are widely distributed across various environments,...

Microbial Morphologies

Microbial Morphologies

Bacterial and archaeal cells exhibit remarkable diversity in shape and structure, critical in their adaptability and functionality. Among bacteria, the most commonly observed shapes include cocci and bacilli. Cocci are spherical and may exist singly or in groupings such as pairs (diplococci), chains (streptococci), clusters (staphylococci), or tetrads. Bacilli, in contrast, are rod-shaped and can also occur as single cells, in pairs, or chains, depending on their environmental and genetic...