与虚弱相关的血代谢特征预测长期死亡风险,并暗示全身衰老途径:来自前性队列研究的证据
Xiru Zhang1,2, Xin Feng1, Wenchao Liu1
1Neurosurgery Center, Department of Cerebrovascular Surgery, The Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
npj aging
|January 12, 2026
概括
脆弱与更高的死亡率有关. 血中的新代谢信号可以识别脆弱性,预测死亡风险,并可能有助于对老龄化人口的早期干预.
科学领域:
- 老年学是指老年学的学科.
- 代谢学 代谢学 代谢学
- 生物统计学 生物统计学
背景情况:
- 虚弱是一种与死亡率相关的老年综合征,但其生物基础和预测价值尚不清楚.
- 了解脆弱的机制对于早期风险分层和老年人的干预至关重要.
研究的目的:
- 识别和验证与身体虚弱相关的血代谢特征.
- 评估这些签名对死亡风险的预测价值.
- 探索这些特征在生物衰老和死亡途径中的作用.
主要方法:
- 来自英国生物银行的一大潜在队列 (超过26万名参与者) 的分析.
- 血代谢分析和弹性网回归用于签名识别和验证.
- 统计分析包括生存分析,调解分析和子组分析 (性别,BMI).
主要成果:
- 识别并验证了身体脆弱的代谢特征和49项的脆弱指数.
- 签名显示稳定性,反映了脂质,氨基酸,能量和炎症通路的变化.
- 较高的签名水平强烈预测了所有原因和特定原因死亡率 (癌症,心血管,呼吸道,消化系统) 的增加,最高三位数的心血管,呼吸道和消化系统死亡风险增加了2.5倍.
- 60岁时超过中位数签名水平的个人预期寿命估计减少4.1年.
- 代谢学特征解释了高达35%的脆弱性与死亡率的关联,在年轻人中影响更强,性别和BMI的变化.
结论:
- 血代谢特征是身体脆弱和生物衰老的强有力的指标.
- 这些特征为预测老龄化人口的早期死亡风险提供了显著的潜力.
- 研究结果支持开发个性化预防策略,针对与脆弱相关的代谢途径.
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