迷幻的5-HT2A激动剂增加了视觉和后皮层中的自发和唤起的5Hz振荡
Callum M White1,2, Zohre Azimi1, Robert Staadt1
1Optical Imaging Group, Institut für Neuroinformatik, Ruhr University Bochum, Bochum, Germany.
Communications biology
|January 12, 2026
概括
视觉皮层中的低频脑振荡 (5 Hz) 与感知有关. 一种针对血清素受体的药物放大了这些振荡,这表明视觉幻觉和上向下感知控制的机制.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
背景情况:
- 心理物理研究表明,低频率 (0.5-7 Hz) 的脑振荡调节知觉和认知状态.
- 在高时空尺度上,5 Hz (theta/alpha-like) 振荡对皮质活动和异常大脑状态的作用尚不清楚.
研究的目的:
- 研究5赫兹振荡对皮质活动和感知的贡献.
- 探索5-HT2AR激动剂对视觉皮层和后皮层5 Hz振荡的影响.
主要方法:
- 在清醒的小鼠中对整个皮层的群体电压成像.
- 记录了自发和视觉唤起的5 Hz振荡.
- 分析了注射5-HT2AR激动剂的效果.
主要成果:
- 视觉皮层中5 Hz振荡的发作与后皮层中类似的振荡相关.
- 这些振荡发生在自发和视觉刺激期间.
- 5-HT2AR激动剂增加了自发的5 Hz振荡,并增强了视觉唤起的5 Hz振荡 (功率,概率,持久性).
结论:
- 5赫兹振荡的调制表明,对知觉的上下控制得到了加强.
- 这为感知填充和视觉幻觉提供了潜在的机制.
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