巴宝丹的机制在甲诱导的骨髓抑制和T细胞通过MAPK通路的免疫障碍
Shuo Yan1,2,3, Ruihan Sun2,3,4, Jie Yuan2,3,4
1People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, 350004, Fujian Province, China.
Scientific reports
|January 12, 2026
概括
巴宝丹 (BBD) 通过恢复T淋巴细胞平衡和增强免疫细胞增殖来保护抗化疗诱导的骨髓抑制. 这种传统的中国草药化合物支持造血功能和免疫平衡.
科学领域:
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
- 传统中国医药 传统中国医药
背景情况:
- 化疗,如5-甲 (5-FU),通常会导致骨髓抑制,导致免疫功能障碍.
- 传统的中国草药化合物,如Babao Dan (BBD),被用作辅助剂,但它们的机制尚不清楚.
- 了解BBD对免疫细胞群和信号通路的影响对于优化癌症治疗至关重要.
研究的目的:
- 调查BBD对5-FU诱导的骨髓抑制和T淋巴细胞变化的影响.
- 探索BBD通过MAPK信号通路改善免疫功能障碍的机制.
- 评估BBD在化疗期间恢复免疫平衡的潜力.
主要方法:
- 小鼠接受了5-FU治疗,以诱导骨髓抑制,随后进行BBD管理.
- 评估了周围血液细胞计数,脏指数和骨髓血液形成.
- 分析了T淋巴细胞亚群 (Th1/Th2),T细胞激活标志物 (CD25,CD69,Ki67,PCNA) 和细胞周期蛋白.
- 量化了MAPK信号通路蛋白 (ERK,p38,NF-κB) 的含量.
主要成果:
- 在接受5FU治疗的小鼠中,BBD改善了生存率,体重和指数.
- BBD缓解了周围血液细胞减少和骨髓抑制.
- BBD恢复了Th1/Th2平衡,增强了T细胞的激活和增殖,并使骨髓细胞的细胞循环正常化.
- BBD调节MAPK信号通路蛋白质,促进G1/S阶段过渡和髓状细胞增殖.
结论:
- BBD有效地减轻了5-FU诱导的骨髓抑制和免疫功能障碍.
- BBD增强T细胞的激活,增殖,并恢复免疫的平衡.
- BBD的机制涉及调节MAPK信号通路并促进髓状细胞循环的进展.
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