基于网络的分析差异性白质连接在大型抑郁症中与并发性焦虑症或没有并发性焦虑症
Marius Gruber1,2,3, Jan Schulte1, Marco Mauritz1
1Institute for Translational Psychiatry, University of Münster, Münster, Germany.
概括
大型抑郁症 (MDD) 与焦虑症 (ANX) 显示大脑连接性增加,而没有ANX的MDD显示连接性减少. 这挑战了共患MDD和ANX的失联假设.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 大型抑郁症 (MDD) 通常被视为一种失联综合征.
- 伴随性焦虑障碍 (ANX) 在MDD中很普遍,但在神经成像研究中通常未被检查.
- 之前的研究还没有充分探索MDD的结构连接性差异,包括并发性ANX和无并发性ANX.
研究的目的:
- 调查MDD患者的结构性大脑连接性改变,有或没有并发性ANX.
- 将MDD患者 (有/没有ANX) 的脑网络与健康对照 (HC) 进行比较.
- 探索焦虑症状严重程度和结构连接性之间的关系.
主要方法:
- 利用了781名MDD患者和906名HC患者的结构和扩散权重的MRI数据.
- 为所有参与者重建结构性大脑网络.
- 雇员基于网络的统计 (NBS) 分析网络层面的连接差异.
- 进行了跨诊断分析,以评估焦虑与连接性的关系.
主要成果:
- 与HC相比,没有ANX的MDD患者显示结构连接性下降.
- 患有并发性ANX的MDD患者表现出相对于HC的结构连接性增加.
- 两组都显示了重叠白质连接的变化.
- 增加的焦虑症状与所有组的结构连接性增加相关.
结论:
- 超连接性,而不是低连接性,是MDD与共患ANX的结构连接体的特征.
- 失联综合征假设可能不完全适用于共患ANX的MDD.
- 需要进一步的基于症状的研究来理解精神障碍中的大脑变化.
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