爪子能讲述一个肺部故事吗? 关于牛皮和肺高血压风险的横截面研究
Sharang Gupta1, Dimple Chopra2
1Department of Dermatology, Civil Hospital, Nabha, Patiala, Punjab, India.
Journal of cutaneous medicine and surgery
|January 12, 2026
概括
指甲牛皮的严重程度,通过指甲牛皮严重程度指数 (NAPSI) 测量,独立预测牛皮患者的肺动脉高血压 (PAH). 较高的NAPSI分数与增加的PAH风险相关,这表明指甲评估是识别需要进一步心脏评估的患者的工具.
科学领域:
- 皮肤病学和心脏病学
- 系统性炎症性疾病系统性炎症性疾病
- 心肺合并性疾病 心肺合并性疾病
背景情况:
- 牛皮是一种系统性炎症性疾病,与心肺问题有关.
- 根据NAPSI的评估,指甲牛皮表明严重的疾病.
- 肺动脉高血压 (PAH) 在牛皮中更常见,但其与指甲牛皮严重程度的联系尚不清楚.
研究的目的:
- 检查NAPSI得分与牛皮患者的PAH存在/严重程度之间的关系.
- 要确定指甲牛皮的严重程度是否是PAH的独立预测因素.
主要方法:
- 一项针对100名牛皮患者的前性,横截面研究.
- 皮肤学评估 (PASI,NAPSI),心声学 (PASP测量) 和炎症标志物的评估 (CRP,IL-17,TNF-α).
- PAH定义为PASP>35 mmHg;统计分析包括相关性和回归.
主要成果:
- 在29%的患者中发现了PAH,在指甲牛皮患者中更为普遍 (40%vs18%).
- 较高的NAPSI分数与较高的PASP相关 (r=0.44,P<.001).这些分数与更高的PASP相关.
- NAPSI,PASI和CRP是PAH的独立预测因素;指甲矩阵参与显示出更强的关联.
结论:
- NAPSI,PASI得分和CRP水平可以预测牛皮患者的PAH.
- 指甲牛皮的严重程度评估可以识别患有肺血管并发症风险较高的患者.
- 对于高风险的牛皮患者,建议进一步进行心脏病评估.
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