精神分裂症的多基因风险预测测试测和自我报告的认知表现在没有精神病的个体
Elena Rosenqvist1, Leo-Pekka Lyytikäinen2,3,4, Elina Sormunen5
1Department of Psychology, Faculty of Medicine, University of Helsinki, P.O. Box 21, Haartmaninkatu 3, Helsinki, 00014, Finland.
BMC psychiatry
|January 12, 2026
概括
精神分裂症 (PRSSCZ) 的高多基因风险与没有精神病的个体的认知表现较差有关. 这些发现表明遗传倾向,而不仅仅是疾病,影响认知困难.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
- 认知神经科学 认知神经科学
背景情况:
- 精神分裂症与认知缺陷有关,部分原因是药物副作用等二次因素.
- 多基因风险评分 (PRS) 提供了对复杂疾病遗传倾向的见解.
研究的目的:
- 调查精神分裂症多基因风险 (PRSSCZ) 与认知表现之间的关联.
- 区分遗传影响的认知表现和与疾病相关的因素.
主要方法:
- 利用了基于人口的年轻芬兰人研究 (n=2217) 的数据,不包括患有精神病的个人.
- 使用全基因组关联研究数据计算PRSSCZ.
- 通过剑桥神经心理测试自动化电池评估认知功能和自我报告的执行功能.
主要成果:
- 较高的PRSSCZ与所有测试认知领域 (视觉空间学习,反应时间,注意力,执行功能) 的较低得分相关.
- 在控制健康行为和社会经济因素后,这些关联仍然很重要.
- PRSSCZ与随着时间的推移增加的刚性有关,但与自我报告的分心或任务导向无关.
结论:
- 患有精神分裂症的高多基因责任的个体表现出类似于被诊断为精神分裂症患者的认知障碍.
- 认知障碍可能部分源于遗传倾向,而不是仅仅源于疾病或其后果.
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