代谢健康的肥胖是否会增加膝盖和手关节炎的风险? 一个基于人口的队列研究
Xusheng Cheng1, Junjie Wang1, Jianqiao Wang1
1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China.
BMC musculoskeletal disorders
|January 12, 2026
概括
肥胖和代谢问题显著增加膝盖和手关节炎的风险. 控制体重对于预防骨关节炎至关重要,特别是在承重关节.
科学领域:
- 类风湿病学 类风湿病学
- 代谢健康 代谢健康
- 流行病学 流行病学
背景情况:
- 骨关节炎 (OA) 是导致残疾的一个重要原因.
- 代谢异常和肥胖是OA的潜在危险因素.
- 了解它们的综合作用对于预防策略至关重要.
研究的目的:
- 研究代谢异常和肥胖对膝关节关节炎 (KOA) 和手关节炎 (HOA) 风险的独立和联合影响.
主要方法:
- 利用了来自389,807名参与者的英国生物库数据.
- 他们将参与者分为四种表型:代谢健康的非肥胖 (MHN),代谢健康的肥胖 (MHO),代谢不健康的非肥胖 (MUN) 和代谢不健康的肥胖 (MUO).
- 采用加速失效时间 (AFT) 模型来评估OA风险.
主要成果:
- 与MHN相比,MHO和MUO都显著加快了KOA发生率.
- MUO加速了HOA的风险.
- MUN还显示KOA发病率增加,但在控制身体质量指数 (BMI) 后,这种影响减少.
- 观察到代谢状态和BMI之间对KOA风险的显著相互作用,更高的BMI在代谢健康的个体中构成更大的KOA风险.
结论:
- 体重指数升高会增加KOA和HOA的风险,无论代谢状态如何.
- 体重指数对KOA风险的影响在代谢健康的个体中更为明显.
- 体重管理是预防骨关节炎的首要策略,特别是在承重关节.
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