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在结性脊柱炎中识别和验证与PANoptosis相关的基因

Zhitao Shan¹, Jiaxin Li¹, Xiaoyu Mu²

¹The First Clinical Medical School, Heilongjiang University of Chinese Medicine, Harbin, 150040, China.

BMC medical genomics

|January 12, 2026

概括

泛亡是一种新的细胞死亡途径,通过六个关键基因驱动结性脊髓炎 (AS) 炎症和骨损伤. 这些基因为AS提供了潜在的诊断和治疗点.

科学领域:

免疫学免疫学免疫学
细胞生物学细胞生物学
遗传学是一个遗传学.

背景情况:

化脊柱炎 (AS) 是一种普遍存在的免疫性炎症性疾病.
在AS病变发生过程中,PANoptosis (一种新的编程细胞死亡途径) 的确切作用尚不清楚.

研究的目的:

为了阐明PANoptosis在AS病变发生中的作用.
识别和验证涉及AS的关键基因 (APR).
为AS诊断和治疗提供新的见解.

主要方法:

对AS基因表达数据集 (GSE25101,GSE73754,GSE11886,GSE134290) 的分析.
微分表达分析 (DEGs),WGCNA,PPI和机器学习 (RF,LASSO,SVM) 的整合.
用完整的弗洛恩德辅助剂 (CFA) 诱导的AS小鼠模型进行验证.

主要成果:

六个核心APRG (AIM2,TNF,IFNG,CASP8,ADAR,ALKBH5) 被确定并与NOD类受体,TNF和p53通路联系在一起.
这些基因通过ROC分析证明了AS的显著诊断疗效.
在体内研究证实了AS模型中关键的APRG和RIPK1以及炎症标志物的表达增加.

结论:

泛亡显著导致AS的慢性炎症和骨破坏.
已确定的六个关键基因 (AIM2,TNF,IFNG,CASP8,ADAR,ALKBH5) 在AS病变发生过程中至关重要.
这些基因代表了有前途的诊断生物标志物和AS干预的治疗点.

关键词:

结性脊柱炎是一种疾病.生物信息学是一种生物信息学.生物标志物生物标志物炎症炎症是一种炎症.这就是PANoptosis.

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