Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cross-reactivity00:42

Cross-reactivity

32.8K
Overview
32.8K
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

1.4K
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
1.4K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

15.9K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
15.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Pro-EGCG suppresses endometriosis progression via regulating monocytic myeloid-derived suppressor cells.

Chinese medicine·2026
Same author

Adversity as the key feature: neuroimaging profiles of subtypes from multiple depression risk factors.

Psychological medicine·2026
Same author

Lyophilizable Thermostable Nano-Aluminum Adjuvant and Combinations Induced Robust Antigen-Specific Humoral and Cellular Immunity in Mice.

Advanced healthcare materials·2026
Same author

Tumor cells metabolically resist immune-checkpoint therapy by macrophage efferocytosis-mediated fatty acid recycling.

Cancer cell·2026
Same author

Genomic insights into intra-specific differentiation and potential evolution of antibiotic resistance/virulence factor genes in Klebsiella oxytoca.

Microbial pathogenesis·2026
Same author

Perilipin-2-Anchored Lipid Droplet-Targeting Phototheranostics.

Angewandte Chemie (International ed. in English)·2026

相关实验视频

Updated: Jan 14, 2026

Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope
08:09

Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope

Published on: March 24, 2017

10.0K

RoBep:一个以区域为导向的深度学习模型,用于预测B细胞位.

Yitao Xu1, Guanyun Wei2, Jingying Zhou3

  • 1Department of Statistics and Data Science, The Chinese University of Hong Kong, Hong Kong SAR, China.

Bioinformatics (Oxford, England)
|January 13, 2026
PubMed
概括
此摘要是机器生成的。

通过模拟空间残留集群,RoBep准确地预测B细胞表位,改善抗体设计和疫苗开发. 这种以区域为导向的预测因素增强了免疫治疗的生物可信性.

更多相关视频

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
07:59

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

Published on: March 25, 2014

15.6K
Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing
08:51

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Published on: March 15, 2019

13.0K

相关实验视频

Last Updated: Jan 14, 2026

Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope
08:09

Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope

Published on: March 24, 2017

10.0K
A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
07:59

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

Published on: March 25, 2014

15.6K
Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing
08:51

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Published on: March 15, 2019

13.0K

科学领域:

  • 计算生物学是一种计算生物学.
  • 免疫信息学是指免疫信息学.
  • 结构生物学是结构生物学.

背景情况:

  • 准确的B细胞表位预测对于抗体设计和疫苗开发至关重要.
  • 当前的方法往往会单独预测残留物,忽视空间连续性和生物可信性.
  • 众所周知,B细胞表位在抗原表面上空间聚集.

研究的目的:

  • 开发一个以区域为导向的B细胞表位预测器,该预测器明确模拟空间残留集群.
  • 提高in silico表位预测的生物可信性和实际相关性.
  • 加强抗体设计和结构导向的疫苗开发.

主要方法:

  • 开发了一种新的面向区域的B细胞表位预测器RoBep.
  • 集成了蛋白质语言模型ESM-Cambrian与等价图神经网络.
  • 引入了一个区域约束机制,以确保预测的表位残留的空间紧性.

主要成果:

  • 在基准数据集上,RoBep显著优于现有的基于结构的方法.
  • 在F1 (26%),MCC (45%),AUPR (13%) 和AUROC0.1 (43%) 中取得了实质性的改进.
  • RoBep既提供了残留水平预测,也提供了具有增强空间紧性的抗体-抗原结合区域.

结论:

  • RoBep提供了一种生物可信和空间连贯的方法来预测B细胞表位.
  • 该方法增强了用于免疫治疗设计的in silico预测的实用性.
  • 在结构导向抗体和疫苗开发方面,RoBep代表了重大进步.