耐受性的更新:改善脏全移植生存率的未来方向
Opas Traitanon1,2, Ekamol Tantisattamo3,4,5,6,7, Suthiya Anumas1,2,8
1Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Thammasat University.
Current opinion in nephrology and hypertension
|January 13, 2026
概括
捐赠者特异性耐受性正在成为移植的临床现实,超越了终身免疫抑制. 混合造血机和调节性T细胞疗法的进步提供了更安全,更持久的移植存活.
科学领域:
- 免疫学 免疫学 免疫学
- 移植医学 移植医学
- 再生医学是一种再生医学.
背景情况:
- 长期代移植的存活受到慢性排斥和免疫抑制毒性的阻碍.
- 捐赠者特异性耐受性,使移植能够在不需要持续治疗的情况下接受移植,是最终的移植目标.
研究的目的:
- 审查移植的耐受性诱导策略最近的临床进展.
- 概述这些耐受性策略的临床翻译的未来方向.
主要方法:
- 临床试验和研究的综述 混合造血混血.
- 在移植中对调控性T细胞 (Treg) 治疗试验的分析.
- 评估条件化方案的进步和受益人的资格.
主要成果:
- 混合造血混血协议已经进入第三阶段试验,显示了持续的无免疫抑制存活率和改善的安全性.
- 监管T细胞疗法在多中心试验中证明了安全性,生物活性和可扩展性,并且正在开发新的方法.
结论:
- 耐受性正在从概念转变为移植的临床可行性.
- 化学反应试验证实,在选定种群中可以实现操作耐受性.
- 未来的工作重点是减少调节方案的毒性,并扩大适应耐受性策略的资格.
相关概念视频
Kidney Transplant I: Introduction
333
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
333
Kidney Transplant III: Nursing Management
307
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
307
Kidney Transplant II: Surgical Procedure
298
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
298
Acute Kidney Injury IV: Diagnostic Studies and Prevention
256
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
256
Tissue Transplantation
888
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
888
Acute Kidney Injury V: Interprofessional Care
294
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
294


