血清维生素与老年人认知障碍之间的关系:基于NHANES数据库的研究
1Basic Medical College, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China.
Brain and behavior
|January 13, 2026
概括
维持足够的维生素D和叶酸 (FA) 水平对于预防老年人认知能力下降至关重要. 维生素B12的高含量可能对患有某些代谢疾病的个体构成风险.
科学领域:
- 老年学是指老年学的学科.
- 营养神经科学 营养神经科学
- 流行病学 流行病学
背景情况:
- 维生素被认为是影响认知健康的可修改因素.
- 维生素对认知的协同或互动作用尚不清楚.
研究的目的:
- 调查血清维生素D,叶酸 (FA) 和维生素B12水平与老年人认知障碍之间的关联.
- 探索与认知健康有关的这些维生素之间的潜在相互作用.
主要方法:
- 来自NHANES (2011-2014) 的2582名老年参与者 (60岁以上) 的数据分析.
- 利用加权后勤回归,贝叶斯核机器回归 (BKMR) 和加权量子量和 (WQS) 模型.
- 进行了敏感性和子组分析,包括对补充剂,抑郁症,睡眠障碍和高维生素B12水平的调整.
主要成果:
- 血清维生素D和FA水平显示与认知障碍风险的反向相关性,即使在调整后.
- 当总体维生素混合物低于50百分点时,BKMR模型表明认知障碍风险增加.
- 观察到维生素B12的U形关联;FA对保护作用的贡献最为显著,并注意到维生素B12和FA之间的相互作用.
结论:
- 优化维生素D和FA是降低认知障碍风险的关键,特别是在补充人群中.
- 维生素B12的管理需要精确,因为高水平可能表明患有特定代谢疾病的患者存在健康风险.
- 研究结果支持对老年人的认知健康进行精确的营养干预.
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