自动血小板测量用于半定量评估高度的肝素:健康志愿者的可行性研究
Marika Pada1,2, Janne Moilanen1, Pasi Ohtonen1,3
1Translational Medicine Research Unit, Medical Research Center Oulu Oulu University Hospital and University of Oulu Oulu Finland.
Health science reports
|January 13, 2026
概括
使用HEPTEM的自动血小板测量可以在心肺旁路术期间监测肝素水平. HEPTEM凝血时间显示了对肝素的剂量依赖反应,有助于安全的抗凝血管理.
科学领域:
- 凝血监测 凝血监测 凝血监测
- 在护理场所进行检测.
- 通过心肺绕道术 (cardiopulmonary bypass) 进行心肺绕道术.
背景情况:
- 在心肺旁路 (CPB) 期间监测深度肝素抗凝剂时,血小板测试尚未被评估.
- 评估肝素度对于CPB的安全性至关重要.
研究的目的:
- 调查自动血小板造影仪用于评估肝素度的可行性.
- 评估HEPTEM在CPB期间监测肝素的潜力.
主要方法:
- 20名志愿者的血液样本中添加了未分离的肝素 (0-6 IU/mL).
- 使用ROTEM Sigma与HEPTEM,INTEM,EXTEM和FIBTEM弹进行粘弹性测试.
- 使用了线性混合模型和ROC曲线分析.
主要成果:
- HEPTEM凝血时间 (CT) 显示,随着肝素度的上升,其线性增加 (p < 0.001).
- ROC分析表明,HEPTEM CT的潜在检测氨酸≥4 IU/mL (AUC = 0.828,p < 0.001) 的潜力.
- INTEM,EXTEM和FIBTEM参数不适合检测CPB适当的肝素水平.
结论:
- 使用HEPTEM的自动血栓形成显微镜显示了剂量依赖的肝素效应.
- 在CPB期间,HEPTEMCT显示出半定量肝素监测的前景.
- 需要进一步的临床研究来证实这些发现.
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