神经退行症在普遍发育障碍的频谱内
Diana Mihalcea1, Marius P Iordache2,3, Claudia Angelescu4
1Psychiatry, Regina Maria Clinic, Bucharest, ROU.
Cureus
|January 13, 2026
概括
历史普遍发育障碍 (PDD) 框架强调神经发育和神经退行过程之间的潜在联系,特别是在自闭症谱系障碍 (ASD) 中. 这表明需要以寿命为导向的护理来解决长期的神经健康问题.
科学领域:
- 神经科学是一个神经科学.
- 发育生物学 发展生物学
- 老年学是指老年学的学科.
背景情况:
- 普遍发育障碍 (PDD) 的历史分类仍然很重要,尽管它被DSM-5的神经发育障碍类别所取代.
- 新出现的证据表明,在以前被诊断为PDD的个体中,神经发育和神经退行性机制之间的交叉关系.
- 像突触修剪,线粒体功能障碍和免疫失调等共享的生物途径表明潜在的长期神经脆弱性,特别是在自闭症谱系障碍 (ASD) 中.
研究的目的:
- 探索神经发育和神经退行性机制的交叉点在以前被归类为PDD的个体中.
- 突出临床重叠的桥梁条件和发展和退行过程之间的连续性.
- 倡导一个整合性的,以寿命为导向的模型,以了解和支持这一群体的长期神经健康.
主要方法:
- 对共享生物通路的新兴证据的审查.
- 在桥梁条件 (例如,雷特综合征,MECP2相关疾病,FXTAS) 中临床重叠的分析.
- 讨论有关ASD认知衰退和衰老的纵向数据缺口.
主要成果:
- 分享的途径 (突触修剪,线粒体功能障碍,免疫失调,蛋白质稳定性受损) 链接神经发育和神经退行过程.
- 桥梁条件说明了发育和退行性疾病之间的连续性.
- 患有自闭症的人面临潜在的认知衰退和非典型衰老的风险,慢性压力和并发症加剧了这种风险.
结论:
- 认识到发育和退行神经科学之间的相互作用为早期神经保护干预和风险分层提供了机会.
- 综合性,以寿命为导向的模型对于描述和支持前PDD构造中的个体的长期神经健康至关重要.
- 需要进一步的纵向研究来了解ASD和相关疾病中与衰老相关的风险.
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