代谢综合征中的自主神经系统失调:与高血压和心血管风险的关联
Hoor Soomra1, Asad Mukhtar2, Fatima Asif3
1Cardiology, University Hospitals Dorset NHS Foundation Trust, Bournemouth, GBR.
Cureus
|January 13, 2026
概括
自主神经系统 (ANS) 失调,标志着对同情和副同情活动的不平衡,与代谢综合征 (MetS) 有关. 这次审查发现了在MetS患者中ANS功能障碍的一致证据,增加了心血管风险.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
背景情况:
- 代谢综合征 (MetS) 涉及腹部肥胖,胰岛素耐药性,失脂症和高血压,增加了2型糖尿病和心血管疾病 (CVD) 的风险.
- 自主性失衡,同情性活动加剧和寄同情性活动减少,在MetS中与高血压和不良心血管事件有关.
研究的目的:
- 系统地审查和评估自主神经系统 (ANS) 失调和代谢综合征 (MetS) 之间的关联.
主要方法:
- 我们对PubMed,Embase,Scopus和Cochrane图书馆 (2015年1月至2025年9月) 进行了系统的搜索.
- 包括的研究检查了在MetS个体中的ANS功能标志物 (HRV,巴罗反射灵敏度,交感神经活动,类甲醇胺).
- 包括16项观察性和干预性研究,并以叙事方式综合数据.
主要成果:
- 大多数研究报告了心率变化 (HRV) 的降低,巴罗反射灵敏度受损,交感神经活动增加,以及MetS参与者的血类甲醇胺含量升高.
- 在MetS中发现ANS失调和高血压之间存在一致的关联.
- 由于大多数研究的观察性质,无法确定因果关系.
结论:
- 显著的证据将自主功能障碍与MetS联系起来,特别是在高血压和心血管风险增加方面.
- ANS生物标志物可能有助于完善心脏代谢风险分层.
- 需要进一步的前性和机制性研究来阐明因果途径.
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