跨越一生的女性特异性高血压风险因素:使用加利福尼亚双胞胎计划的共同双胞胎对照分析
Kellie R Imm1, Wendy Cozen2,3, Kim Siegmund1
1Department of Population and Public Health Sciences, Keck School of Medicine of USC, University of Southern California.
American journal of epidemiology
|January 13, 2026
概括
女性高血压 (HT) 风险与成年早期体重,成年体重和更年期有关. 保持较低的体重和炼更多的双胞胎可以减少HT的几率.
科学领域:
- 遗传学和流行病学
- 生殖健康 生殖健康
- 心血管疾病病因学 心血管疾病病因学
背景情况:
- 双胞胎研究在调查女性特异性高血压 (HT) 原因方面未得到充分利用.
- 不一致的共同双胞胎设计将遗传和早期环境混因素降到最低.
- 了解女性HT病因对于有针对性的预防策略至关重要.
研究的目的:
- 在女双胞胎的生命过程中识别HT相关的因素.
- 为了利用不和的共同双胞胎设计的优势进行可靠的分析.
- 确认已知并发现女性高血压的新风险因素.
主要方法:
- 使用了来自加利福尼亚双胞胎计划 (CTP) 的202对女性双胞胎的不和的共同双胞胎设计.
- 通过基线风险因素问卷和自我报告的HT收集的数据.
- 采用条件逻辑回归,仅限于非吸烟者,并按复合性分层.
主要成果:
- 在18岁时超重 (≥150lbs vs <130lbs) 与三倍的HT概率相关.
- 较高的成年体重 (≥180磅) 与6倍的HT概率相关.
- 与同胞相对增加的运动与0.54倍的HT几率相关;更年期与增加的HT几率相关,特别是在更年期后的DZ双胞胎 (4倍).
结论:
- 青春期和成年期的超重是女性HT的重要危险因素.
- 运动等生活方式因素在HT发展中起着至关重要的作用.
- 更年期是一个关键时期,与女性HT风险增加有关.
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