尽管有效的ART,但HIV相关的神经认知障碍的脑脊髓液中HIV的表达仍然存在
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Updated: Jan 14, 2026

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A Rat Model of EcoHIV Brain Infection
Published on: January 21, 2021
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Gabriela S Prates1,2, Xiaoyi Li2, Victor Folgosi1
1Laboratory of Medical Investigation LIM-56, Division of Dermatology, Faculty of Medicine, University of São Paulo. ZIP Code: 05403-000; São Paulo, SP, Brazil.
Emerging microbes & infections
|January 13, 2026
概括
尽管有效的抗逆转录病毒疗法 (ART),艾滋病毒仍然存在于中枢神经系统 (CNS) 的艾滋病毒感染者 (PWH) 的手. 中枢神经系统中潜伏的非复制性HIV表达可能会导致神经炎症和认知能力下降.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 有效的抗逆转录病毒疗法 (ART) 无法消除艾滋病毒相关的神经认知障碍 (HAND) 在艾滋病毒感染者 (PWH) 中.
- 中枢神经系统 (CNS) 可能存在病毒储存库,原因是ART透率有限,以及血和脑脊液 (CSF) 之间的病毒学不一致.
研究的目的:
- 调查艾滋病毒在ART治疗的PWH中枢神经系统中的持久性和表达,包括HAND和没有HAND.
- 探索在CSF中的ART药物度,HIVRNA,HIV衍生的和神经炎症标志物之间的关系.
主要方法:
- 对24名接受ART治疗的PWH进行横截面研究,分层分为认知正常 (CN) 和HAND组.
- 在配对的血和脑脊液中使用RT-ddPCR量化HIVRNA.
- 通过质谱测量和ART药物度测量通过LC-MS/MS.通过CSF皮层的分析.
- 在CSF中使用病毒外生长试验评估艾滋病毒感染性.
主要成果:
- 在CSF中检测到HIVRNA,但在HAND参与者的血中无法检测到,这表明病毒持续存在.
- 脑脊液中药物度超过了抑制值,但在HAND脑脊液中发现了HIVRNA和HIV衍生的 (Env,Pol).
- 在HAND参与者中观察到β-tau的早期减少,与HIV存在相关.
- 从CSF中没有确立有生产力的HIV感染,这表明非复制性病毒表达.
结论:
- 尽管抑制性ART和足够的药物透,但HIV仍然存在于HAND的PWH中枢神经系统中.
- 潜伏的HIV感染与非复制性病毒表达,而不是活跃的复制,可能有助于HAND的发病.
- 这些发现凸显了针对中枢神经系统艾滋病毒储存库的战略的必要性,以防止神经认知衰退.
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