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用于治疗头部和部癌症的注射式西斯普拉丁加载生物降解聚胺-:临床前研究.

Christine Warwar Damouny1, Narmeen Matta1, Muhammad Abdel Haq2,3

  • 1Intragel Therapeutics LTD., Wadi El Haj 13, PO Box 1252, Nazareth Industrial Area, Nazareth 17111, Israel.

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概括

使用可生物降解聚合物的新型长效西斯烯配方旨在减少头癌患者的严重毒性. 这种方法可能会改善头部和部状细胞癌 (SCCHN) 的治疗坚持和患者结果.

关键词:
在FADU异种移植的过程中美国政府 (P(SARA)可生物降解,可生物降解.西斯普拉丁 (cisplatin) 是一种制剂.头部和部癌症 头部和部癌症可以注射的注射剂.在口内入口.长时间起作用的药物.聚烯化物化物

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科学领域:

  • 在瘤学瘤学.
  • 药物输送系统 药物输送系统
  • 生物材料科学 生物材料科学

背景情况:

  • 标准的第一线治疗不可切割的头和部HPV阴性平细胞癌 (SCCHN) 结合了西斯普拉丁化疗和放射治疗.
  • 西斯的严重全身毒性限制了其在某些患者中的使用,导致治疗不理想和预后较差.
  • 替代疗法效率较低,突出显示需要改进西斯的输送方法.

研究的目的:

  • 调查一种新型的,单剂量,长效的西斯普拉丁配方,以减轻系统性毒性.
  • 评估可生物降解的聚化载体在有针对性,高有效载荷药物输送方面的潜力.
  • 为了提高基斯普拉丁治疗SCCHN的安全性和疗效.

主要方法:

  • 开发一种可注射,可生物降解的聚化载体系统.
  • 使用脂酸 (SA) 和酸 (RA) 制备长期作用的西斯普拉丁.
  • 调查载体在小量,高负载药物输送方面的潜力.

主要成果:

  • 开发的聚化载体系统证明了单剂量,长效西斯的输送潜力.
  • 该配方旨在减少与常规思普拉丁化疗相关的全身毒性.
  • 针对性交付方法旨在提高SCCHN治疗中的治疗疗效.

结论:

  • 一种新的可生物降解的聚化载体为开发一种毒性较低,长效的西斯普拉丁配方提供了一个有前途的战略.
  • 这种创新的药物输送系统可以改善SCCHN患者的治疗坚持和结果.
  • 需要进行进一步的研究,以充分确定这种新西斯普拉丁输送方法的安全性和有效性.