在植物中的木质素多样化之后,Agaricomycetes laccases的适应性进化
Shenglong Liu1,2,3, Qinbiao Yu1,2,3, Tian Yin1,2,3
1School of Life Sciences and Medical Engineering, Anhui University, Hefei, Anhui, China.
Applied and environmental microbiology
|January 13, 2026
概括
白色腐烂真菌中的Laccase异酶进化为优先氧化不同类型的素. 后来的乳酶 (LacA,LacB) 准S型红素,而早期的乳酶 (LacF) 准G型红素,显示与红素合成的共同进化.
科学领域:
- 菌类学 菌类学是指菌类学.
- 生物化学 生物化学
- 进化生物学 进化生物学
背景情况:
- 白色腐烂真菌中的乳糖酶异酶在红素降解中发挥作用,但它们的进化历史仍有争议.
- 特拉梅特斯 hirsuta是一种能够降解纤维素,半纤维素和素的真菌.
研究的目的:
- 为了研究Trametes hirsuta中的laccase异酶的进化史和功能多样化.
- 为了理解乳糖酶进化和红素结构变化之间的关系.
主要方法:
- 在Trametes hirsuta AH28-2.2中对laccase异酶的生物信息和生物化学表征.
- 对laccase基因的转录和表达分析.
- 在体外和体外氧化测定使用素模型化合物.
主要成果:
- 在T. hirsuta AH28-2中,有6个laccase同酶起源于一个单一的祖先基因,形成了三个不同的进化分支.
- 后来出现的乳酸酶 (LacA, LacB) 优先氧化S型木质素 (硬木),而早期的乳酸酶 (LacF) 氧化G型木质素 (软木).
- 对祖先乳酸酶的进化分析显示,红素氧化偏好从G型转变为S型.
结论:
- 在Agaricomycetes真菌中,乳糖酶的演化与S型红素在angiosperm中的出现密切相关.
- 菌乳酶多样化与红素的结构变化共同进化,表明不同类型的红素在不同的进化阶段具有优先氧化.
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