背景黑人与白人种族差异 乳房MRI上对细胞增强
Mattia A Mahmoud1, Jinbo Chen1,2, Christine E Edmonds2,3
1Department of Biostatistics, Epidemiology, & Informatics, Perelman School of Medicine, University of Pennsylvania, 423 Guardian Dr, 833 Blockley Hall, Philadelphia, PA 19104.
Radiology
|January 13, 2026
概括
与白人女性相比,黑人女性在MRI扫描上显示出更高的背景膜增强 (BPE),即使考虑到乳腺密度. 这一发现表明,BPE可能是不同人群中乳腺癌的独立风险因素.
科学领域:
- 放射学和医学成像学 医学成像学
- 在瘤学瘤学.
- 健康方面的种族差异.
背景情况:
- 在对比度增强的MRI上,高背景辅酶增强 (BPE) 与乳腺癌风险增加有关.
- 黑人女性面临更高的乳腺癌死亡率,通常乳腺密度较低,但BPE尚未在这个群体中进行研究.
研究的目的:
- 为了研究黑人和白人女性之间对比度增强的MRI衍生的BPE的种族差异.
- 评估乳腺密度是否介于BPE的种族差异.
主要方法:
- 对没有乳腺癌史的黑人和白人女性进行了回顾性横截面研究,接受了乳房影像和核磁共振.
- 使用乳房成像报告和数据系统标准对BPE (高与低) 的定性评估.
- 后勤回归和调解分析,以评估种族,BPE和乳腺密度的关联.
主要成果:
- 与白人女性相比,较少的黑人女性的乳房非常密集 (11%对21%).
- 同样比例的黑人和白人女性表现出高BPE (38%对33%).
- 在对乳腺密度进行控制后,黑人女性患高BPE的可能性增加了31% (OR,1.28;95%CI:1.01,1.64).
结论:
- 黑人女性在MRI上比白人女性更有可能有高的BPE,无论乳腺密度如何.
- BPE可能作为一种独立的乳腺癌风险标志物,特别是在多样化的人口中.
- 需要进一步的研究来了解BPE对黑人女性的临床影响.
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