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Updated: Jan 14, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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路径独立的正调节器C1允许识别活性Y4受体的相关位置

Corinna Schüß1, Oanh Vu2, Tim Pelczyk3

  • 1Institute of Biochemistry, Leipzig University, 04103, Leipzig, Germany. corinna.schuess@uni-leipzig.de.

Cellular and molecular life sciences : CMLS
|January 13, 2026
PubMed
概括

研究人员确定了C1,一种新的阳性全调节器 (PAM) 对神经Y4受体 (Y4R). C1增强了Y4R信号传递和带结合,为和能量平衡调节提供了新的治疗途径.

关键词:
这里是Allostery.通过GPCR调制进行GPCR调制.变异发生的突变.神经贝Y4受体是神经贝Y4的受体.胰腺多是一种胰腺多.受体的药理学受体的药理学

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