使用石油基膏剂会导致PRESERFLO微型的胀
Ryo Tomita1, Taiga Inooka1, Takato Kajita2
1Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Aichi, Japan.
概括
基于石油的眼科膏在PRESERFLO MicroShunts中引起显著的胀和结构性损害. 避免在暴露于MicroShunts的患者中使用这些药膏,以防止设备故障.
科学领域:
- 眼科医生 眼科 眼科
- 生物材料科学 生物材料科学
- 玻璃眼治疗方法 玻璃眼治疗方法
背景情况:
- PRESERFLO MicroShunt是一种用于治疗青光眼的设备.
- 眼科膏通常用于眼部护理.
- 医疗器械和药物之间的潜在相互作用需要调查.
研究的目的:
- 为了记录临床案例的PRESERFLO MicroShunt在暴露于石油基眼科药膏后的胀.
- 通过实验确定胀的MicroShunts的原因和组成.
主要方法:
- 眼病患者的回顾性病例系列,有胀的MicroShunts.
- 在体外实验中,使用未使用的MicroShunts在0.3%的洛克萨眼药膏中化.
- 使用显微镜和质子核磁共振 (1H-NMR) 光谱的时间过程沉浸研究.
主要成果:
- 暴露于膏的MicroShunts在24小时内显示出明显的胀,脆性和骨折.
- 在24小时内,外径增加1.44倍,翅膀宽度增加1.29倍.
- 胀的器件在24小时后约占55%的SIBS和45%的药膏,在3个月后转变为27%的SIBS和73%的药膏.
结论:
- 基于石油的眼科膏和基于SIBS的MicroShunt之间的直接接触会引起时间依赖的胀.
- 这种胀损害了微型冲击器的结构完整性.
- 在暴露于MicroShunts的患者中,应避免使用眼科膏.
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