动脉样硬化中的性别差异及其临床并发症
Tina K Reddy1, Emily Littman1, Petal Elder-Odame2
1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Current atherosclerosis reports
|January 13, 2026
概括
妇女面临更大的心血管风险来自传统因素,如糖尿病和吸烟. 独特的风险和治疗不足强调了需要个性化的动脉样硬化治疗,解决性别特异性的差异.
科学领域:
- 心血管医学 心血管医学
- 性别和性别在健康中的作用
背景情况:
- 动脉样硬化病理生理学,表现和并发症表现出显著的性别和性别特异性变异.
- 了解这些差异对于公平的心血管疾病 (CVD) 护理至关重要.
研究的目的:
- 审查动脉样硬化的性别和性别特异性差异.
- 探索影响女性不成比例的传统和新兴风险因素.
- 为了确定女性动脉样硬化患者的诊断和治疗缺口.
主要方法:
- 在动脉样硬化中检查性别和性别的研究的文献综述.
- 对风险因素,临床表现和结果的分析.
- 评估当前的诊断和治疗策略.
主要成果:
- 传统的风险因素 (糖尿病,吸烟) 在女性中构成更高的心血管疾病风险.
- 女性独特的风险因素包括不良妊娠结果,PCOS,早期更年期和自身免疫性疾病.
- 妇女在非阻塞性冠状动脉疾病 (INOCA/MINOCA) 中患有较多的缺血症,并且接受的预防性治疗较少.
- 高风险的斑块特征在女性中具有更大的预后重量,尽管整体斑块负担较小.
结论:
- 动脉样硬化的性别和性别差异需要量身定制的预防和治疗策略.
- 解决诊断和治疗差异对于改善女性心血管健康至关重要.
- 个性化护理承认独特的女性风险概况对于推进公平的心血管疾病管理至关重要.
相关概念视频
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
455
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
455
Atherosclerosis I: Introduction
890
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
890
Coronary Artery Disease I: Introduction
869
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
869
Atherosclerosis III: Management
312
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
312
Atherosclerosis IV: Nursing Management
361
Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
361
Coronary Artery Disease III: Clinical Manifestations
317
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
317


