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在胸前大动脉手术期间对纤维素缩物用于静血的评估 (完整的再版)
Akihiko Usui1,2, Kenji Minatoya3, Kenji Okada4
1Department of Cardiac Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. akihiko.usui@fujita-hu.ac.jp.
General thoracic and cardiovascular surgery
|January 13, 2026
概括
纤维素缩物有效地改善了血液凝固,并在患有低纤维素生成血症的患者的大动脉手术期间减少出血. 这种治疗迅速增加了纤维素水平,并增强了内在和外在的凝血功能.
科学领域:
- 心血管外科心血管外科
- 麻醉学 麻醉学
- 血液学 血液学 血液学
背景情况:
- 低纤维素生成血是重大手术期间出血的危险因素.
- 维持足够的纤维素素水平对于血液静止至关重要.
研究的目的:
- 评估纤维素缩剂在改善凝血和控制出血方面的疗效.
- 评估纤维素度在大动脉手术期间对凝血参数的影响.
主要方法:
- 研究了32名接受胸腔或胸腔腹腔大动脉手术的患者,这些患者患有低纤维素生成血症 (<150毫克/分升).
- 使用ROTEM Sigma®监测凝血.
- 在3分钟内量化了手术内出血.
主要成果:
- 纤维素度显著增加纤维素水平 (109至231毫克/分升),并减少了3分钟的出血 (144至85毫升).
- 在注射纤维素缩物后,FIBTEM A10,EXTEM A10和INTEM A10值显著改善.
- 没有发生手术死亡,但有三个血栓栓塞事件 (心肌梗塞,脑梗塞).
结论:
- 纤维素缩剂有效地快速增加纤维素水平,并减少大动脉手术期间的出血.
- 缩剂的使用显著改善了外部和内在的凝血参数.
- 虽然对出血有效,但潜在的血栓栓塞风险需要仔细考虑.
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