对抗雄激素滥用减少危害干预的有效性:一项历史控制试验
Tijs Johannes Verdegaal1,2, Willem de Ronde1, Manon Jansen2
1Department of Internal Medicine, Spaarne Gasthuis, Boerhaavelaan 22, 2035 RC, Haarlem, the Netherlands; Department of Endocrinology and Metabolism, Amsterdam UMC, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.
European journal of endocrinology
|January 13, 2026
概括
减少危害的干预措施显著降低了男性运动员的雄激素暴露. 这种方法有望减轻与雄激素滥用相关的健康风险.
科学领域:
- 运动医学运动医学
- 公共卫生 公共卫生
- 内分泌学 在内分泌学.
背景情况:
- 类固醇类固醇 (AAS) 的滥用正在提高性能和图像增强.
- 预防性努力在制AAS滥用方面取得了有限的成功.
- 缺乏对AAS滥用的危害降低策略进行评估的受控试验.
研究的目的:
- 评估降低男性业余运动员中AAS滥用的降低危害降低干预措施的有效性.
- 评估个性化咨询和医疗评估对AAS使用模式的影响.
主要方法:
- 一个为期一年的前性,历史控制的干预研究.
- 包括99名计划开始AAS周期的男性业余运动员.
- 干预组接受了咨询和医疗评估;与没有接受干预的历史队列 (n=100) 相比.
主要成果:
- 干预组12%的参与者没有开始AAS循环.
- 与对照组相比,干预组的平均累积雄激素剂量显著降低 (13,087 mg的减少).
- 干预效应独立于基线差异,没有观察到启用效应.
结论:
- 这是第一个控制研究表明,减少伤害干预措施可以减少计划滥用AAS的男性的雌激素暴露.
- 研究结果支持降低伤害作为一种可行的策略,以减轻与AAS滥用相关的健康风险.
- 需要进一步的研究来确认可通用性,并监测潜在的启用效应.
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