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相关概念视频

Disorders of the Female Reproductive System01:24

Disorders of the Female Reproductive System

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The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
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The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
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Menopause01:28

Menopause

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Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
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The Menstrual Cycle01:19

The Menstrual Cycle

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The menstrual cycle is a recurrent sequence of changes in the uterine endometrium, specifically its functional layer, the stratum functionalis. This cycle prepares the uterus for potential pregnancy. This cycle typically spans 21–35 days, averaging 28 days, and aligns with the ovarian cycle, regulated by fluctuating levels of ovarian hormones, primarily estrogen and progesterone.
The menstrual phase occurs from days 1 to 5 and involves the shedding of the stratum functionalis, as a...
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The uterine cycle begins with the menstrual phase, which is considered day one of the cycle and typically lasts about five days. This phase is characterized by the degeneration and shedding of the stratum functionalis, the functional layer of the endometrium.
When fertilization does not occur, the corpus luteum deteriorates, causing a significant drop in the levels of estrogen and progesterone in the body. This hormonal decrease triggers the release of prostaglandins, which cause the uterine...
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The secretory phase of the menstrual cycle, spanning from day 14 to 28 in a typical 28-day cycle, is a period of significant physiological changes in the female reproductive system. This phase commences immediately after ovulation and is characterized by the preparation of the endometrium for potential embryo implantation.
Following ovulation, the corpus luteum, a temporary endocrine structure, produces progesterone and estrogens. These hormones stimulate the growth and coiling of endometrial...
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与teprotumumab相关的月经变化

Amina Malik1,2,3, Patrick J Hunt1,4, Tracy Lu1,5

  • 1Department of Ophthalmology, Houston Methodist Hospital, Houston, Texas, USA.

Orbit (Amsterdam, Netherlands)
|January 13, 2026
PubMed
概括
此摘要是机器生成的。

对甲状腺眼病 (TED) 的teprotumumab治疗导致了55%的患者的月经变化,包括缺血症. 大多数女性经历治疗后恢复正常月经,但对于提供者来说,意识至关重要.

关键词:
在IGF-1的基础上,IGF-1甲状腺眼睛疾病 甲状腺眼病亚美诺雷亚 亚美诺雷亚 是一种经期 经期 经期 经期这就是为什么teprotumumab.

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科学领域:

  • 内分泌学 在内分泌学.
  • 眼科医生 眼科 眼科
  • 生殖健康 生殖健康

背景情况:

  • 甲状腺眼部疾病 (TED) 是一种影响轨道的自身免疫性疾病.
  • 德图穆马布是一种新型的生物药物,用于积极的TED治疗.
  • 月经周期不规则是全身疗法的潜在,未被报告的不良影响.

研究的目的:

  • 确定接受teprotumumab治疗的患者月经周期变化的发生率和特征.
  • 为了记录月经变化的类型及其与teprotumumab输注的时间关系.

主要方法:

  • 在三个机构 (2020-2023) 中,对51名接受teprotumumab治疗的女性患者进行了回顾性图表审查.
  • 收集的数据包括患者人口统计,甲状腺状况,荷尔蒙避孕药的使用,以及月经周期数据 (类型,发病,持续时间).
  • 还记录了临床活动得分和不良事件.

主要成果:

  • 55%的患者 (28/51) 经历了月经变化.
  • 最常见的变化是阿门 (75%) 和寡门 (21%).
  • 第一次输液后大约58天发生了月经不规则,平均在治疗后155天恢复正常月经;14%的人在最后一次随访时没有恢复正常周期.

结论:

  • 月经周期障碍是与TED妇女teprotumumab治疗相关的常见不良事件.
  • 门和小门是主要观察到的变化.
  • 医疗保健提供者应为患者提供关于在teprotumumab治疗期间可能出现月经不规则的建议.