与teprotumumab相关的月经变化
Amina Malik1,2,3, Patrick J Hunt1,4, Tracy Lu1,5
1Department of Ophthalmology, Houston Methodist Hospital, Houston, Texas, USA.
Orbit (Amsterdam, Netherlands)
|January 13, 2026
概括
对甲状腺眼病 (TED) 的teprotumumab治疗导致了55%的患者的月经变化,包括缺血症. 大多数女性经历治疗后恢复正常月经,但对于提供者来说,意识至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 眼科医生 眼科 眼科
- 生殖健康 生殖健康
背景情况:
- 甲状腺眼部疾病 (TED) 是一种影响轨道的自身免疫性疾病.
- 德图穆马布是一种新型的生物药物,用于积极的TED治疗.
- 月经周期不规则是全身疗法的潜在,未被报告的不良影响.
研究的目的:
- 确定接受teprotumumab治疗的患者月经周期变化的发生率和特征.
- 为了记录月经变化的类型及其与teprotumumab输注的时间关系.
主要方法:
- 在三个机构 (2020-2023) 中,对51名接受teprotumumab治疗的女性患者进行了回顾性图表审查.
- 收集的数据包括患者人口统计,甲状腺状况,荷尔蒙避孕药的使用,以及月经周期数据 (类型,发病,持续时间).
- 还记录了临床活动得分和不良事件.
主要成果:
- 55%的患者 (28/51) 经历了月经变化.
- 最常见的变化是阿门 (75%) 和寡门 (21%).
- 第一次输液后大约58天发生了月经不规则,平均在治疗后155天恢复正常月经;14%的人在最后一次随访时没有恢复正常周期.
结论:
- 月经周期障碍是与TED妇女teprotumumab治疗相关的常见不良事件.
- 门和小门是主要观察到的变化.
- 医疗保健提供者应为患者提供关于在teprotumumab治疗期间可能出现月经不规则的建议.
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