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Updated: Jan 15, 2026

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
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Published on: January 26, 2024

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ME-pKa:一种深度学习方法,使用多模式学习来预测蛋白质pKa

Shanshan Shi1, Runyu Miao1, Danlin Liu2,3

  • 1Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.

Journal of chemical theory and computation
|January 13, 2026
PubMed
概括

一个新的多式模式模型,ME-pKa,通过整合本地环境和序列数据,准确地预测蛋白质pKa值. 这一进步有助于理解蛋白质功能和药物设计,特别是对于挑战埋藏的残留物.

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