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介素-9 调节NF-kB介导的星球细胞激活在多发性硬化症的大脑

Miriam Cinotti^1,2, Susanna Amadio³, Daniele Tidei¹

¹Molecular Neuroimmunology Unit, IRCSS Santa Lucia Foundation, Rome, Italy.

Neurology(R) neuroimmunology & neuroinflammation

|January 13, 2026

概括

干白素-9 (IL-9) 通过平静反应性星球细胞和抑制促炎信号来减少多发性硬化症 (MS) 的炎症. 这表明IL-9可能是MS治疗的潜在治疗标.

科学领域:

神经免疫学神经免疫学
细胞免疫学细胞免疫学

背景情况:

在多发性硬化症 (MS) 的大脑组织中,介素-9 (IL-9) 受体 (IL-9R) 表达表明IL-9具有保护作用.
星球细胞是MS病变的关键参与者,变得有反应性,并导致中枢神经系统炎症.
核因子-kB (NF-kB) 在中枢神经系统炎症期间控制反应性星球细胞反应.

研究的目的:

在多发性硬化症患者中研究中枢神经系统居民细胞中的IL-9R表达.
确定IL-9在调节星细胞炎症反应,特别是NF-kB激活中的作用.
探索IL-9对像GM-CSF这样的天体细胞衍生的促炎媒介的影响.

主要方法:

使用了三种人体体内体外天体细胞模型:天体细胞瘤细胞系 (U-373 MG),初级正常人体天体细胞和诱导多能干细胞衍生天体细胞.
诱导星球细胞的预炎性反应使用互白素-1β.
评估IL-9对NF-kB激活和GM-CSF表达的影响.

主要成果:

星球细胞表达IL-9R,证实了它们对IL-9的反应.
发现IL-9可以降低星球细胞中NF-kB激活的调节,使其转向抗炎特征.
IL-9抑制了NF-kB驱动的粒细胞-巨细胞殖民地刺激因子 (GM-CSF) 表达.

结论:

IL-9通过抑制由天体细胞衍生的GM-CSF,微质激活的关键媒介来调节天体细胞-微质轴.
这些发现凸显了IL-9在MS中具有潜在的治疗性抗炎作用.
准IL-9信号传递可能为管理多发性硬化症中神经炎症提供一种新的策略.

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