相关实验视频
Updated: May 11, 2026

11:13
A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity
Published on: July 12, 2018
在社区实施双特异抗体:从ThedaCare癌症中心经验中吸取教训
Kehua Zhou1, Leah Ebben2, Binod Dhakal3
1Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO.
JCO oncology practice
|January 13, 2026
概括
社区癌症中心可以通过建立多学科团队,教育计划和电子病历 (EMR) 工具来成功实施T细胞双特异抗体 (bsAb) 治疗,以管理诸如细胞因子释放综合征 (CRS) 和神经毒性等毒性.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 血液学恶性瘤是什么
背景情况:
- 双特异性T细胞抗体 (bsAbs) 在血液癌症中提供高响应率,但存在毒性挑战 (CRS,ICANS).
- 社区癌症中心面临着有限的文献和实施BSAb疗法的实际障碍.
- 现成的bsAbs的可用性与社区环境中的挑战形成鲜明对比.
研究的目的:
- 在ThedaCare癌症中心审查社区对bsAb治疗的实施.
- 突出学习经验和在整合bsAb治疗中持续存在的挑战.
- 为更广泛的社区采用新型癌症疗法提供框架.
主要方法:
- 任命了一个项目冠军,并组建了一个多学科的bsAb团队.
- 开发了教育模块和集成的EMR决策支持工具 (订单集,BPA).
- 针对识别和管理bsAb相关毒性 (CRS,ICANS) 的专注培训.
主要成果:
- 通过结构化策略,成功地在社区实施bsAb疗法.
- 药剂师在药物处理,毒性管理和财务物流方面发挥了关键作用.
- 电子电磁记录工具促进了对潜在副作用的早期干预.
结论:
- 社区实施bsAb治疗需要机构承诺,护理人员教育和财务导航.
- 结构化的工作流程,关于CRS和ICANS的综合患者/提供者教育,以及24/7的支持至关重要.
- 这种经验为在社区环境中实施类似的创新癌症疗法提供了一个模型.
相关概念视频
Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Vaccines
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

