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药物诱导的无菌性脑膜炎:对病例报告的25年系统审查

Madhusudan Prasad Singh¹, Riya Yadav¹, Juhi Singh²

¹Department of Pharmacology, All India Institute of Medical Sciences, Raipur, Chhattisgarh.

Clinical neuropharmacology

|January 13, 2026

概括

药物诱导的无菌性脑膜炎 (DIAM) 模仿感染,需要仔细诊断. 及时识别和药物审查是有效管理这种罕见药物不良反应的关键.

科学领域:

神经学神经学
药理学药理学是指药理学的学科.
传染性疾病传染性疾病

背景情况:

药物诱导的无菌性脑膜炎 (DIAM) 是一种罕见但显著的不良药物反应.
DIAM经常模仿传染性脑膜炎,使诊断和管理变得复杂.
需要进行系统性审查来描述DIAM并改善临床实践.

研究的目的:

系统地审查和描述药物诱导的无菌性脑膜炎 (DIAM).
从已发表的病例报告和系列中综合数据,以提高诊断准确度.
引导药物诱导的无菌性脑膜炎的管理策略.

主要方法:

在多个数据库 (PubMed/MEDLINE,Scopus,Embase,Cochrane Library,ClinicalTrials.gov) 和灰色文献中进行全面的文献搜索.
遵守PRISMA系统审查指南.
包括具有详细临床和治疗数据的病例.

主要成果:

分析了98份报告,涉及108名患者;平均年龄为47岁,55%为女性.
通常涉及的药物包括NSAID,抗生素和单克隆抗体.
典型症状:头痛 (78%),发烧 (65%),部硬 (56%);17%的人有严重的神经问题. 脑脊液显示有多细胞形成 (65%) 和蛋白质增加 (60%).

结论:

由于其模仿传染性脑膜炎,DIAM诊断需要高度的临床怀疑和彻底的药物历史.
迅速识别和停止使用违规药物对于解决方案至关重要.
对免疫病原发生和基于证据的DIAM治疗方法的进一步研究是有必要的.

关键词:

案例报告,病例报告.皮质类固醇是什么药物诱导的无菌性脑膜炎一个单克隆抗体.非类固醇抗炎药物是指非类固醇抗炎药物.

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