更年期和多发性硬化症:对症状,疾病过程和生活经验的范围审查
Dawn Morgan1, Victoria Aviado Flores2, Stephanie Buxhoeveden1
1Accelerated Cure Project for Multiple Sclerosis, 406 Totten Pond Rd, Waltham, MA, 02451, USA.
Maturitas
|January 13, 2026
概括
更年期可能会加速多发性硬化症的进展,恶化神经退行和症状,尽管炎症减少. 需要对更年期和女性多发性硬化症 (MS) 进行更多研究.
科学领域:
- 神经学 神经学
- 妇女健康 妇女健康
- 生殖医学 生殖医学
背景情况:
- 更年期对患有多发性硬化症 (MS) 的女性的疾病活动产生重大影响.
- 了解更年期和MS之间的相互作用对于管理疾病进展和患者福祉至关重要.
研究的目的:
- 进行范围审查,绘制现有证据,对MS妇女的绝经进行评估.
- 分析症状,疾病,生物和生活经验领域的发现.
主要方法:
- 搜索了六个主要数据库 (PubMed/MEDLINE,Embase,Web of Science,Scopus,CINAHL,PsycINFO) 在2018年1月1日至2025年4月29日之间发表的研究.
- 包括涉及患有多发性硬化症 (前,更年期或更年期后) 和更年期相关结果的妇女的研究.
- 在四个关键领域描述性地合成数据.
主要成果:
- 包括19项研究,主要是观察性研究,有各种更年期定义.
- 绝经后复发活动减少,但神经退行和功能衰退恶化.
- 症状加剧并与衰老重叠;没有捕捉到患者的定性观点.
结论:
- 更年期可能会加速MS的进展,其特点是炎症减少,但神经退行和症状负担增加.
- 研究的局限性包括不一致的更年期定义,缺乏年龄特定的框架,以及缺乏定性数据.
- 临床医生应该认识到重叠的症状,为患有多发性硬化症的妇女提供个性化的护理.
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