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基于频谱-疗效关系的不同物种的Epmedii Folium的质量评估

Zhichen Cai¹, Jia Xue¹, Yongyi Zhou¹

¹College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.

Computational biology and chemistry

|January 13, 2026

概括

叶片 (EF) 的质量因物种而异. 一个全面的方法确定了icariin,quercitrin和epimedin B作为生物标志物,EBM显示了缺乏症的优越质量和有效性.

科学领域:

药理学是指药理学,即药理学是指药理学.
传统中国医药传统中国医药
分析化学分析化学

背景情况:

叶 (Epimedii Folium,简称EF) 是一种具有可变活性成分的传统中医药.
这种变化导致商业药物材料的质量不一致.
标准化的质量评估对于可靠的治疗用途至关重要.

研究的目的:

开发一种全面的方法来评估来自四种不同物种的Epimedii Folium质量.
为了确定对治疗效果负责的潜在生物标志物.
为了在不同物种中比较Epimedii Folium的质量和有效性.

主要方法:

超高性能液态染色学与三次飞行时间质谱学 (UPLC-Triple TOF-MS/MS) 结合,用于指纹采集.
建立一种腺因诱导的缺陷小鼠模型,用于有效性评估.
多变量统计分析 (灰色相关性分析和双变量相关性分析).
超高性能液体染色学与QTRAP质谱仪 (UPLC-QTRAP MS/MS) 结合使用,用于生物标志物识别.

主要成果:

在四个Epimedium物种的40个批次中确定了12个常见的峰值.
与模型组相比,在接受治疗的老鼠中,脏和丸病变显著改善.
灰色相关性分析和双变相关性分析表明,伊卡林,奎瑞特林和Epimedin B作为潜在的生物标志物.
与其他物种相比,EBM的epimedin B和icariin水平显著更高,与药理学发现相关.
所有经过测试的EF品种都对缺陷表现出保护作用,EBM表现出优越的质量.

结论:

开发的综合方法有效地评估不同物种的Epimedii Folium质量.
伊卡里因,奎瑞特林和Epimedin B被确定为关键的潜在生物标志物.
Epimedii Folium EBM在治疗缺乏症方面表现出卓越的质量和有效性.
这项研究为Epimedii Folium的质量控制和评估提供了基本数据.

关键词:

在Epmedii Folium中使用.不同的物种,不同的物种.黄类化合物黄类化合物多变量统计分析多变量统计分析同时确定同时确定.

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