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在血友病B中经过PK引导过渡到延长半衰期的因子IX后,药理动力学,出血控制和成本分析的改善:一项多中心研究

Maria Chovi-Trull1, Juan Eduardo Megías-Vericat1, Tomás Palanques-Pastor1

  • 1Pharmacy Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain.

Thrombosis research
|January 13, 2026
PubMed
概括

切换到延长半衰期的XIX因子缩剂 (FIX-EHL) 显著改善了B型血友病患者的药理动力学参数和降低了出血率. 虽然输液频率和剂量下降,但转换并没有降低整体治疗成本.

关键词:
第九因子:因子IX.半衰期 半衰期 半衰期血友病B型 血友病B型 血友病药理动力学 药理动力学预防 预防 预防

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