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Chemical Shift: Internal References and Solvent Effects01:17

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In an NMR sample, precise measurement of the absolute absorption frequencies of nuclei is difficult. A standard internal reference compound is added, and the frequency difference between the reference signal and sample signals is measured.
The internal reference compound generally used in NMR spectroscopy is tetramethylsilane (TMS). TMS is preferred because it is chemically inert, soluble in NMR solvents, and easily removable. Also, the highly shielded methyl protons in TMS yield an intense...
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Data Validation01:15

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Method validation is a crucial process in analytical chemistry designed to confirm that a given method consistently produces reliable and high-quality results. This process is essential when a method is applied to different sample matrices or when procedural modifications are made, ensuring that the results meet acceptable standards across various applications.
Key parameters for method validation include:
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Therapeutic Drug Monitoring: Drug Analysis Methods01:26

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Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
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开发和验证用于三放射性分析比较程序的参考材料.

Donghye Heo1, Myoungjung Kim2, Byoungchul Kim2

  • 1Radioactivity Group, Korea Research Institute of Standard and Science(KRISS), 267, Gajeong-ro, Yuseong-gu, Daejeon, 34113, Republic of Korea; Division of Earth Environmental System Sciences-Major of Environmental Geosciences, Pukyong National University, 45 Yongso-ro, Nam-gu, Busan, 48513, Republic of Korea.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
|January 13, 2026
PubMed
概括

这项研究开发了用于放射性紧急准备的经过验证的参考材料. 这些材料提高了内部剂量评估的可靠性,并在整个东亚标准化了生物测试方法.

关键词:
生物测试是一种生物测试.标志性描述 标志性描述相互比较 相互比较低水平放射性的低水平放射性活动.稳定的稳定性 稳定的稳定性三是三中的一种.验证 验证 验证 验证

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科学领域:

  • 环境科学 环境科学
  • 辐射健康 辐射健康
  • 分析化学 分析化学

背景情况:

  • 对放射性紧急情况的区域准备要求可靠的内部剂量评估.
  • 对生物测试方法的标准化对于准确的暴露评估至关重要.

研究的目的:

  • 开发和验证含尖的尿样和低水平的参考材料.
  • 加强东亚地区对放射性紧急情况的区域准备.
  • 为了标准化内部暴露的分析方法.

主要方法:

  • 通过添加经过认证的参考材料来制备尖尿液.
  • 评估尿样的一致性和稳定性.
  • 通过重力度稀释生产低水平的三参考材料.
  • 使用ANOVA和液体闪计数评估均性和活性度.

主要成果:

  • 经验证的三参考材料显示均分布 (±10%) 和极小的挥发性.
  • 分析可靠性通过低根平均平方误差 (RMSE) 值 (5.06%和10.5%) 得到证实.
  • 低水平的三参考材料显示高精度,效率偏差为0.2%.

结论:

  • 经过验证的参考材料和协议为协调东亚的生物测试技术提供了基础.
  • 这些结果支持内部暴露评估和区域合作监测的标准化.
  • 该研究提高了管理放射性紧急情况和改善剂量评估的能力.