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在中国中部分离的犬类冠状病毒的鉴定和疫苗疗效评估

Xiaoyu Zhang¹, Ying Li², Xin Liu¹

¹National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China; Hubei Jiangxia Laboratory, Wuhan 430200, China.

Veterinary microbiology

|January 13, 2026

概括

一种新的毒性犬类冠状病毒 (CCoV) 菌株WH2023被确定. 使用这种菌株的非活化疫苗显示出出色的安全性,并为狗的CCoV感染提供了长期的保护.

科学领域:

兽医病毒学兽医病毒学
狗的传染病狗的传染病

背景情况:

狗冠状病毒 (CCoV) 在狗中引起肠道疾病,高突变率影响病毒力和疫苗疗效.
新型病毒性CCoV菌株的出现构成了重大威胁,特别是在养所.

研究的目的:

为了隔离和表征一种新型病毒性CCoV菌株.
开发和评估一种针对新型CCoV菌株的非活化疫苗.

主要方法:

来自中国的新型CCoV菌株 (WH2023) 的隔离和遗传学分析.
在小狗中进行致病性研究,以评估病毒性.
在小狗中开发和评估用GEL02作为辅助剂的非活化WH2023疫苗,评估安全性和免疫性.

主要成果:

新型WH2023菌株被确定为一种高度毒性的CCoV-IIa亚型.
用非活化WH2023疫苗接种疫苗显示出极好的安全性,并诱导高中和抗体标位 (1:5404).
接种疫苗的狗完全免受挑战,持续抗体水平超过1:32300天,超过商业疫苗.

结论:

WH2023代表了一个显著的毒性CCoV-IIa菌株.
开发的无活化疫苗为增强安全性和长期保护犬类冠状病毒感染提供了一个有希望的解决方案.

关键词:

这是CCoV-IIa亚型.狗的冠状病毒病毒.没有活化的疫苗.隔离隔离隔离隔离

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