澳大利亚越南战争退伍军人可采取行动的药物:预防性药物遗传测试的含义
Wei Liang Andre Tan1, Rebecca Mellor1, Darcy Bennett2
1Gallipoli Medical Research, Greenslopes, QLD, Australia; The University of Queensland, Brisbane, QLD, Australia.
概括
澳大利亚越南退伍军人经常服用多种药物,许多人携带遗传特征,增加了药物不良反应的风险. 药物遗传检测可以提高他们和老年人的药物安全性.
科学领域:
- 药物遗传学 药物遗传学
- 临床药理学 临床药理学
- 退伍军人健康 退伍军人的健康
背景情况:
- 澳大利亚越南退伍军人经历了高水平的多药.
- 了解对药物代谢的遗传倾向对于优化治疗至关重要.
研究的目的:
- 描述澳大利亚越南退伍军人的药物处方模式.
- 为了确定由CYP2C19代谢的药物,并评估药物遗传学 (PGx) 影响.
- 根据退伍军人的CYP2C19概况,评估这些药物的临床影响.
主要方法:
- 澳大利亚越南退伍军人队伍中CYP2C19遗传资料的表征.
- 对当前药物使用的分析和药物的鉴定与CYP2C19药物遗传学建议.
- 评估潜在的药物基因和药物相互作用,包括CYP2C19抑制剂和诱导剂.
主要成果:
- 在283名具有CYP2C19配置文件的退伍军人中,89名 (34.7%) 接受了至少一种具有PGx推的药物.
- 52名退伍军人 (58.4%) 拥有与潜在治疗失败或不良反应相关的CYP2C19概况.
- 处方药包括六种CYP2C19抑制剂和一种诱导剂,构成转化风险.
结论:
- 退伍军人表现出高多药性,并携带与增加风险相关的CYP2C19表型.
- 存在CYP2C19抑制剂/诱导剂可以导致转化,影响药物代谢.
- 建议对退伍军人和老年人进行预防性药物遗传检测和持续监测,以提高药物的安全性和有效性.
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