在低剂量LSD后的参与者中,与抑郁情绪相关的奖励神经活动
James Glazer1, Hanna Molla2, Royce Lee2
1Department of Psychiatry, Northwestern University, Chicago, IL, USA.
Journal of psychopharmacology (Oxford, England)
|January 13, 2026
概括
低剂量的lysergic acid diethylamide (LSD) 可以通过改变大脑对奖励的反应来帮助减少抑郁症. 这项研究发现,在患有轻度至中度抑郁症的参与者中,LSD增加了积极的心情,并减少了抑郁症状.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- Lysergic acid diethylamide (LSD) 作为一种潜在的抑郁症治疗药物,有着悠久的历史.
- 微剂量LSD被假设可以缓解抑郁症状,但其神经生物学机制尚不清楚.
- 以前的研究表明,LSD会影响与奖励处理和情绪相关的事件相关潜力 (ERP).
研究的目的:
- 研究LSD对抑郁症和没有抑郁症的个体的奖励相关ERP的影响.
- 探索LSD潜在抗抑郁作用的神经生物学基础.
主要方法:
- 一项双盲,安慰剂控制的研究,涉及轻度至中度抑郁症的参与者和健康的对照.
- 在两个会议中服用低剂量的LSD (26μg) 或安慰剂.
- 在奖励任务中测量事件相关潜力 (ERP),并评估自我报告的情绪.
主要成果:
- 作为对失败与胜利的反应,LSD增加了晚期积极潜力 (LPP) 幅度,特别是在基线抑郁症较高的参与者中.
- 这种LSD诱导的LPP变化与急性积极的情绪效应相关,并在会议后48小时减少了抑郁症状.
- 在所有参与者中,LSD降低了与反相关的P3和LPP幅度,用于奖励与中性反.
结论:
- 研究结果表明,低剂量的LSD可能具有抗抑郁药的特性.
- 观察到对ERP,特别是LPP的影响,表明对奖励的情感评估发生了变化.
- 需要进一步的研究来证实这些初步发现,并探索治疗应用.
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