三十年的葡萄牙语非洲的临床试验:一个全面的范围检查审查协议协议
Jorge Pedro Barroso Batista1,2, Maria Manuel Teixeira3, Carla de Matos Torre3,4
1Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa, Lisbon, Portugal jorge.batista@ordemfarmaceuticos.pt.
BMJ open
|January 13, 2026
概括
本范围审查绘制了1995-2024年葡萄牙语非洲国家 (PSAC) 随机临床试验 (RCT) 的地图. 它确定了研究趋势,疾病和差距,以了解该地区的临床试验演变.
科学领域:
- 临床研究 临床研究
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
背景情况:
- 发表的临床试验提供了对葡萄牙语非洲国家 (PSAC) 研究格局的见解.
- 这是第一个全面的范围审查,以检查PSAC的临床试验格局.
- 这些国家包括安哥拉,佛得角,几内亚比绍,圣多美和普林西比和莫桑比克.
研究的目的:
- 系统地绘制和分析随机临床试验 (RCT),评估从1995年到2024年在PSAC进行的药理干预.
- 确定研究趋势,目标疾病,地理分布和证据差距.
- 了解PSAC地区临床试验的发展和演变.
主要方法:
- 坚持乔安娜·布里格斯研究所的范围审查方法,遵循阿克西和奥马利框架 (由Levac等人改进). 和PRISMA扩展范围审查指南.
- 通过使用4个电子数据库 (MEDLINE,EMBASE,African Index Medicus,Cochrane Central) 和3个临床试验注册表 (ClinicalTrials.gov,ICTRP,PACTR) 的双重搜索策略.
- 提取试验特征,疾病,阶段,设计,资金和道德合规性;使用Cochrane RoB工具V.2.0.0.0评估偏差风险.
主要成果:
- 分析研究趋势,向性疾病和PSAC中RCT的地理分布.
- 确定该地区临床试验研究中的证据缺口.
- 将PSAC与其他地理区域之间的临床研究范围进行比较,考虑疾病概况.
结论:
- 该审查提供了PSAC临床试验环境的全面概述.
- 结果将为未来的研究重点和该地区临床试验开发战略提供信息.
- 通过同行评审的出版物,会议演讲和葡萄牙语和英语的社交媒体传播.
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