Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Small GTPases - Ras and Rho01:24

Small GTPases - Ras and Rho

Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
Three regulatory proteins control their activity:

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A reassessment of NMDA receptor-dependent presynaptic homeostatic plasticity.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Early life Oxytocin treatment Attenuates Seizure Susceptibility in Male, but not Female, <i>Fmr1</i>-KO Mice.

bioRxiv : the preprint server for biology·2026
Same author

A depression-like phenotype is associated with discrete defects in the primary hippocampal circuit.

Translational psychiatry·2026
Same author

Lasting effects of early-life oxytocin treatment on LTP and episodic memory in a mouse model of Fragile X syndrome.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same author

A concise mathematical description of signal transformations across the hippocampal apical CA3 to CA1 dendritic response.

Frontiers in neural circuits·2026
Same author

Hippocampal estrogen levels, receptor types, and epigenetics contribute to sex-specific memory vulnerabilities to concurrent acute stresses.

Neuron·2026

相关实验视频

Updated: Jun 21, 2026

Dissection of Hippocampal Dentate Gyrus from Adult Mouse
07:42

Dissection of Hippocampal Dentate Gyrus from Adult Mouse

Published on: November 17, 2009

83.9K

在小鼠海马体中MDGA1的定位和功能特征.

Matthew A Sandoval1,2, Michael A Bemben3, Gerardo Leana-Sandoval1,2

  • 1Department of Anatomy & Neurobiology, University of California at Irvine, CA, 92617, USA.

The Journal of neuroscience : the official journal of the Society for Neuroscience
|January 13, 2026
PubMed
概括

含有MAM域的甘氨酸酸基蛋白1 (MDGA1) 在突触中没有丰富,并且不调节年轻小鼠的突触传播. 这一发现澄清了MDGA1的定义.

更多相关视频

Assessment of Dendritic Arborization in the Dentate Gyrus of the Hippocampal Region in Mice
10:55

Assessment of Dendritic Arborization in the Dentate Gyrus of the Hippocampal Region in Mice

Published on: March 31, 2015

10.7K
Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
07:43

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

11.7K

相关实验视频

Last Updated: Jun 21, 2026

Dissection of Hippocampal Dentate Gyrus from Adult Mouse
07:42

Dissection of Hippocampal Dentate Gyrus from Adult Mouse

Published on: November 17, 2009

83.9K
Assessment of Dendritic Arborization in the Dentate Gyrus of the Hippocampal Region in Mice
10:55

Assessment of Dendritic Arborization in the Dentate Gyrus of the Hippocampal Region in Mice

Published on: March 31, 2015

10.7K
Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
07:43

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

11.7K

科学领域:

  • 神经科学是一个神经科学.
  • 分子生物学分子生物学
  • 突触性可塑性 突触性可塑性

背景情况:

  • 突触组织分子对于神经元通信,突触形成和可塑性至关重要.
  • 据说MDGA1,一种与GPI结的蛋白质,可以抑制突触形成,并与精神疾病有关.
  • 之前对MDGA1体内局部化和功能的研究已经产生了相互矛盾的结果.

研究的目的:

  • 精确定义MDGA1在小鼠大脑中的定位和功能.
  • 调查MDGA1在 hippocampus 中调节突触传输中的作用.

主要方法:

  • 用表位标记的MDGA1敲入小鼠 (雄性和雌性) 的生成.
  • 在产后发育期间,前脑中MDGA1表达模式的分析.
  • 切片电生理学,以评估急性MDGA1删除对海马CA1.1突触传播的影响.

主要成果:

  • 在出生后早期的几周内,MDGA1表达在前脑中达到顶峰.
  • 在海马CA1中,MDGA1定位在树突上,但不是专门用于激发性或抑制性突触.
  • MDGA1的急性缺失没有影响激发性或抑制性突触传播.

结论:

  • MDGA1暂时居住在年轻小鼠的海马突触中,但不是突触传播的强有力的调节者.
  • 这些发现挑战了MDGA1作为直接突触组织分子的拟议作用.
  • 需要进一步的研究才能充分阐明MDGA1在神经系统中的功能.