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Updated: Jan 15, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA
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从偏见的MD模拟中推断DNA亲属性

Arianna Fassino1, Enrico Carlon1, Aderik Voorspoels1,2

  • 1Soft Matter and Biophysics, KU Leuven, Celestijnenlaan 200D, Leuven B-3001 Belgium.

Journal of chemical theory and computation
|January 13, 2026
PubMed
概括

机械压力会导致DNA扭曲,这取决于序列. 两种曲类型,扭曲曲和纯曲,来自DNA变形,影响生物过程.

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Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
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