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Updated: Jan 15, 2026

Murine Model of CD40-activation of B cells
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在乳腺癌中,激进的CD40引发了CD8+T细胞依赖的初级反应和CD4+T细胞依赖的长期免疫力

Casey Lam1, Olivia Lanchoney1, Vishnu Maddipatla1

  • 1Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.

NPJ breast cancer
|January 13, 2026
PubMed
概括

激动性CD40抗体 (aCD40) 增强了乳腺癌的免疫检查点阻塞 (ICB) 治疗. 将aCD40与ICB结合起来表明了疫苗效应,导致瘤排斥,并在临床前模型中降低毒性.

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