相关实验视频
Updated: Jan 15, 2026

08:50
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
16.7K
评估和治疗慢性病中的代谢酸症:基于注册表的研究
Mai Tanaka1,2, Michihiro Hosojima3, Hideyuki Kabasawa1
1Department of Clinical Nutrition Science, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, 1-757 Asahimachi-dori, Chuo-ku, 951-8510.
Scientific reports
|January 13, 2026
概括
代谢性酸 (MA) 在慢性病 (CKD) 患者中很常见,但在日本经常被诊断不足和治疗不足. 这项研究发现日本CKD患者的MA的二碳酸盐测量率低,诊断/治疗率差.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内部医学 内部医学
- 公共卫生 公共卫生
背景情况:
- 代谢性酸化 (MA) 是慢性病 (CKD) 患者的常见并发症.
- 指导方针建议MA治疗,但在西方国家报告的诊断不足和治疗不足.
- 亚洲CKD人群中MA的患病率和管理仍然不清楚.
研究的目的:
- 评估日本CKD患者的血清二碳酸盐测量率.
- 为了确定这一群体中MA的患病率,诊断和治疗率.
- 评估在日本CKD患者中MA评估和管理的充分性.
主要方法:
- 使用了日本慢性病数据库 (J-CKD-DB-Ex).
- 包括18岁以上的患者,其eGFR为15-60毫升/分钟/1.73平方米,从2014年至2021年.
- 分析了血清二碳酸盐测量率,MA流行率 (血清二碳酸盐<22mEq/L),以及使用ICD-10代码和处方的诊断/治疗率.
主要成果:
- 年度血清二碳酸盐测量率始终低于10%.
- 在至少进行一次测量的患者中,MA的患病率为44.2%.
- 对MA的诊断和治疗率较低,分别为8.6%和7.5%.
结论:
- 在日本的CKD患者中,血清二碳酸盐测量是不常见的.
- 代谢性酸性是普遍存在的,但在这个队列中诊断和治疗不充分.
- 调查结果表明,在日本CKD护理中,在MA管理方面存在潜在的差距.
相关概念视频
Chronic Kidney Disease III: Interprofessional Care
335
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
335
Renal Regulation of Acid-Base Balance
1.5K
Metabolic reactions in the body produce nonvolatile acids, such as sulfuric acid, which generate an acid load of approximately 1 mEq of H+ per kilogram of body weight daily. Excreting H+ in the urine is essential to balance this acid load.
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
1.5K
Acute Kidney Injury V: Interprofessional Care
295
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
295
Diagnosing Acidosis and Alkalosis
1.0K
Diagnosing acid-base imbalances involves systematically analyzing arterial blood samples, focusing on three key measurements: pH, bicarbonate (HCO3−) concentration, and carbon dioxide partial pressure (PCO2). This analysis follows a four-step process that helps identify the imbalance's underlying cause and nature.
First, the pH level is assessed to determine whether the blood pH is normal (7.35–7.45), low (acidosis), or high (alkalosis).
Next, the PCO2 and...
First, the pH level is assessed to determine whether the blood pH is normal (7.35–7.45), low (acidosis), or high (alkalosis).
Next, the PCO2 and...
1.0K
Acute Kidney Injury IV: Diagnostic Studies and Prevention
257
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
257
Chronic Kidney Disease I: Introduction
557
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
557

