轻度至中度克罗恩病患者的禁食模仿饮食:一个随机对照试验
C Kulkarni1, T Fardeen1, J Gubatan1
1Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, USA.
Nature medicine
|January 13, 2026
概括
短周期的禁食模仿饮食 (FMD) 显著改善了克罗恩病 (CD) 患者的临床反应和缓解. 与标准饮食相比,口病显示出更好的结果,减少了炎症标志物.
科学领域:
- 胃肠病学和肝病学
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 众所周知,短周期的禁食模仿饮食 (FMD) 可以减少炎症并改善健康个体的代谢健康.
- 口病的疗效以前没有在克罗恩氏病 (CD) 患者中进行研究,克罗恩氏病是一种慢性炎症性疾病.
研究的目的:
- 评估仿制禁食饮食 (FMD) 对患有轻度至中度克罗恩病 (CD) 的成年人临床结果的影响.
- 评估口病对CD患者炎症标志物和代谢健康的影响.
主要方法:
- 进行了一项开放的随机对照试验,对成年患者进行了轻度至中度CD的诊断.
- 参与者被随机分为两组:一个是每月接受5天口炎治疗,持续3个月,另一个控制组维持了基线饮食.
- 主要结局是临床反应,定义为CD活动指数 (CDAI) 的降低或CDAI得分≤150.
主要成果:
- 与对照组 (43.8%) (P=0.03) 相比,口和口腔炎组的患者比例显著更高,达到临床反应 (69.2%).
- 口疫组的临床缓解率 (64.6%) 与对照组 (37.5%) (P=0.02) 相比也显著更高.
- 与对照组相比,口疾病干预导致便calprotectin显著降低,这是一个关键的炎症标志物 (-22.0%对8.0%,P=0.03).
结论:
- 禁食模仿饮食 (FMD) 在改善轻度至中度克罗恩病 (CD) 的临床反应,缓解和生化标志物方面优于标准饮食.
- 口病显示出作为治疗慢性炎症疾病 (如CD) 的辅助疗法的潜力.
- 需要进一步的研究来探索口热在炎症条件下的长期益处和机制.
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