与恐慌症相关的结构性大脑差异:ENIGMA-焦虑工作组对全球4924名个人进行了大型分析
Laura K M Han1,2,3,4, Willem B Bruin5,6,7,8, Janna Marie Bas-Hoogendam9,10,11
1Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. l.han@amsterdamumc.nl.
Molecular psychiatry
|January 13, 2026
概括
大规模的神经成像揭示了恐慌障碍 (PD) 中的大脑结构差异. 患有PD的个体表现出皮质厚度和皮质下体积的改变,特别是在成年期,这表明发育和衰老的影响.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 神经解剖学是一个神经解剖学.
背景情况:
- 在恐慌障碍 (PD) 中复制神经解剖学发现是具有挑战性的,因为效果不一致.
- 转向大规模,协作的神经成像研究是强有力的检查PD的大脑相关的关键.
- 埃尼格玛焦虑工作组已经编制了PD最大的多站点神经成像数据库.
研究的目的:
- 研究与健康对照组 (HC) 相比,患有恐慌症 (PD) 个体的大脑结构差异.
- 为了检查这些神经解剖学差异的年龄相关变异.
- 探索早期疾病发作和PD中大脑结构之间的潜在关联.
主要方法:
- 利用了最大的PD多站点神经成像数据库 (N=1146 PD,N=3778 HC;年龄10-66岁).
- 对皮层厚度,皮层表面积和皮层下体积进行了分析.
- 研究了根据年龄的诊断相互作用和早期疾病发病的子组分析.
主要成果:
- 与HC相比,患有PD的个体表现出较低的前--双叶皮层厚度和表面积,以及较低的thalamic和caudate体积.
- 根据年龄的诊断相互作用表明,在成年期 (25-55岁) 的PD中皮质厚度减少.
- 早期疾病发作 (≤21岁) 在PD中与较大的侧心室有关;没有发现药物,并发症或严重性的影响.
结论:
- 这些发现支持神经电路模型的PD涉及前额 - 皮 - 边缘和temporo-parietal区域.
- 异常的大脑发育和衰老可能在PD观察到的神经解剖学差异中发挥重要作用.
- 这项大规模的研究代表了识别恐慌障碍的结构性大脑相关的里程碑.
更多相关视频
10:43Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
Published on: July 1, 2014
15.7K
09:14Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
Published on: March 14, 2025
902
相关概念视频
01:27Panic Disorder
621
Panic disorder is an anxiety disorder characterized by recurrent and sudden minutes-long episodes of intense fear, known as panic attacks. These attacks may feel like heart attacks and often happen without warning or a specific cause. They can include symptoms such as rapid heart rate, shortness of breath, chest pain, trembling, sweating, dizziness, and a sense of helplessness. During a panic attack, individuals may feel as though they are experiencing a heart attack or are in a...
621
01:30Generalized Anxiety Disorder
627
Generalized Anxiety Disorder (GAD) is a chronic condition characterized by excessive and uncontrollable worry that persists for at least six months, significantly interfering with daily functioning. Unlike situational anxiety, which arises in response to specific stressors, GAD often occurs without a clear cause. Individuals may experience disproportionate worry about work, health, or relationships. For instance, a person might continuously fear poor health despite normal medical evaluations or...
627