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静脉血细胞比率作为预测力缺血性中风中再生输液结果的指标:系统性审查和元分析

István Szegedi^1,2, Zsolt Barnabás Éles^2,3, Attila Nagy^2,4

¹Department of Neurology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Neurology and therapy

|January 13, 2026

概括

治疗前中性粒细胞与淋巴细胞比率 (NLR) 的升高预测急性缺血性中风 (AIS) 患者接受再输液治疗的结果和死亡率不佳. 这种简单的生物标志物有助于在静脉输血栓溶解或机械血栓切除术后早期风险分层.

科学领域:

神经学神经学
血液学血液学血液学
生物标志物生物标志物

背景情况:

炎症是急性缺血性中风 (AIS) 病理生理学的核心.
血细胞计数比率,像中性粒细胞与淋巴细胞比率 (NLR) 一样,是潜在的预后生物标志物.
它们在接受再输血治疗 (IVT/MT) 的AIS患者中的有用性尚不清楚.

研究的目的:

系统地评估接受再注射治疗的AIS患者治疗前血细胞比率的预后值.
评估这些比率与临床结果之间的关联,包括功能状态和死亡率.

主要方法:

按照PRISMA指南,对主要数据库 (PubMed,Cochrane,科学网,Scopus) 进行系统的文献搜索.
包括在IVT或MT治疗的AIS患者中报告治疗前血细胞比率和修改的兰金尺度 (mRS) 结果的研究.
使用随机效应模型对合并的赔率比率 (ORs) 的元分析.

主要成果:

分析了57项涉及17394名患者的研究.
在MT (OR 1.09, 1.05) 和IVT (OR 1.11) 分组中,高的NLR显著预测了3个月的不良结果和更高的死亡率.
其他比率 (LMR,PLR,MLR,PNR) 显示不一致或无关联;LMR表明有保护作用.

结论:

治疗前的NLR是AIS再注射治疗后不良结果和死亡率的一致预测指标.
在这些患者中,NLR作为一种有价值的,简单的生物标志物,用于早期风险分层.
需要进一步的大型前性研究来证实炎症比率在中风管理中的临床实用性.

关键词:

急性缺血性中风是一次急性缺血性中风.在静脉内进行血栓溶解.机械血栓切除术是一种机械血栓切除术.中性粒细胞与淋巴细胞的比率.治疗结果的治疗结果.静脉血液细胞比率的比率.

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