α-synucleinA2A

Yan He1,2, Jiamin Zhu3, Xiaoqing Liu3

  • 1The Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China.

概括

在帕金森病 (PD) 中的α-synuclein聚合会损害执行功能. 阻断腺A2A受体 (A2AR) 逆转了这些缺陷,为PD相关的执行功能障碍提供了潜在的治疗标.